关键词: 胃肠胰神经内分泌肿瘤, 细胞系, 类器官模型, 人源肿瘤异种移植模型, 基因工程小鼠模型

Abstract:

Gastroenteropancreatic neuroendocrine neoplasm (GEP-NEN) is a rare, heterogeneous tumor that can be divided into neuroendocrine tumor (NET) and neuroendocrine carcinoma (NEC) due to its degree of differentiation. With the gradual deepening of the exploration of its pathogenesis and treatment methods, the importance of preclinical models has become increasingly prominent. Here we reviewed the published preclinical models such as cell lines, organoid models, patient-derived xenograft models and genetically engineered mouse models. We also discussed the current practical applications of these models and their strengths and weaknesses, to provide threads and directions for future research.

Key words: Gastroenteropancreatic neuroendocrine neoplasm, Cell line, Organoid model, Patient-derived xenograft model, Genetically engineered mouse model