关键词: 癌, 肿瘤内微生物, 肿瘤免疫微环境, 宏基因组测序

Abstract: Intratumoral microbiome is defined as the microbes that reside within tumor tissues to form the tumor
microenvironment. Although substantial advances have been made in the research on virus infection and cancer during the past
century, little is known about the existence and the role of intratumoral bacteria or fungi in cancer. In recent years, with the
development of high-throughput sequencing technology, evidence has emerged to support the existence and functional activity of
intratumoral bacteria. This review summarized the recent research progress in intratumoral microbiome, particularly their contribution
to the carcinogenesis and chemoresistance of breast cancer, pancreatic cancer and lung cancer. The future perspectives of intratumoral
microbiota in clinical application were also discussed.

Key words: Cancer, Intratumoral microbiome, Tumor immune microenvironment, Metagenome sequencing