关键词: 口腔癌；荧光成像技术；荧光探针；诊断 &nbsp,

Abstract: The main clinical problems in treatment of oral cancer are tumor recurrence and metastasis after surgery. To improve
the efficiency of resection and the prognosis of patients is a key to curing oral cancer. Fluorescence imaging, as an adjuvant in the
diagnosis and treatment of oral cancer with no invasion and radiation, can provide real-time and ultrahigh-resolution graphics for
preoperative tumor diagnosis, intraoperative tumor margin determination and postoperative tumor bed checking, which can help
reduce the recurrent rate, enhance the survival rate and improve the life quality of patients. This article reviewed several typical
fluorescent probes and discussed their characteristics, limitations and application prospects in clinic or research for oral cancer.

Key words: Oral cancer, Fluorescence imaging technology, Fluorescent probe, Diagnosis