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摘要/Abstract

摘要：

背景与目的：近年来国产放疗设备及相关软件发展迅速，检验设备和软件的功能性及稳定性是必不可少的环节，本研究主要比较uRT-治疗计划系统（treatment planning system，TPS）和Monaco-TPS在常见癌症调强适形放疗（intensity-modulated radiation therapy，IMRT）计划剂量学和危及器官（organ at risk，OAR）体积计算方面的差异，评估使用uRT-TPS对Infinity直线加速器（瑞典Elekta公司）进行剂量计算的可行性。方法：选取直肠癌、肺癌、乳腺癌和鼻咽癌共20例患者作为研究对象，分别在uRT-TPS和Monaco-TPS中对各病例完成IMRT计划制订。在计划靶区（planning target volume，PTV）处方剂量体积相同条件下比较靶区剂量均匀性、适形性和OAR的平均剂量、最大剂量等参数。在同一直线加速器中比较验证uRT-TPS和Monaco-TPS的通过率。对比uRT-TPS和Monaco-TPS在计划跳数（monitor units，MU）、源皮距（source skin distance，SSD）和OAR的重建体积差异。结果：uRT-TPS和Monaco-TPS均可获得满足临床要求的放疗计划。靶区剂量具有可比拟的均匀性和适形性，uRT-TPS在靶区的最大剂量平均降低1.1 Gy（P = 0.006）。对于乳腺癌和肺癌，Monaco-TPS的正常肺组织剂量较低（P<0.05）。对于鼻咽癌，uRT-TPS在口腔和咽喉的剂量指标分别降低9.2%和5.1%。uRT-TPS和Monaco-TPS的点绝对剂量（<3%）和三维面剂量（>95%）验证结果均满足临床要求。uRT-TPS感兴趣区的体积计算小于Monaco-TPS（P<0.05）。结论：对于常见肿瘤的放疗计划，uRT-TPS可以优化出与Monaco-TPS同等水平的IMRT计划。使用uRT-TPS对Infinity直线加速器进行剂量计算具有可行性。

关键词: 调强适形放疗, uRT-治疗计划系统, Monaco-治疗计划系统

Abstract:

Background and Purpose: In recent years, domestic radiotherapy equipment and related software have made great progress, and testing the functionality and stability of the equipment and software is an essential step. This paper focused on comparing the differences in intensity-modulated radiation therapy (IMRT) plans dosimetry and organ at risk (OAR) volume calculations for common cancers between uRT-treatment planning system (TPS) and Monaco-TPS, and to evaluate the feasibility of dose calculation for Infinity linac (linear accelerator, Elekta, Sweden) using uRT-TPS. Methods: Twenty cases of rectal cancer, lung cancer, breast cancer and nasopharyngeal carcinoma were selected. The IMRT plans were completed in uRT-TPS and Monaco-TPS. The dose uniformity and conformity, mean dose, maximum dose of planning target volume (PTV) and OAR between two plans under the same prescribed dose of PTV were compared. And the pass rates of two TPS plans validated at the same linear accelerator were compared. Meanwhile, monitor units (MU), source skin distance (SSD) and the volume of OAR in uRT-TPS and Monaco-TPS were compared. Results: Wonderful plans that met the clinical requirements were obtained in uRT-TPS and Monaco-TPS. Comparable uniformity and conformability was received in PTV, and the maximum dose of PTV was reduced by 1.1 Gy for uRT-TPS (P = 0.006). For breast cancer and lung cancer, the dose in lung was lower for Monaco-TPS (P<0.05). For nasopharyngeal carcinoma, the dose indicators that oral cavity and throat in the uRT-TPS was reduced by 9.2% and 5.1%, respectively. The verification results of absolute point dose (<3%) and three-dimensional surface dose (>95%) for both plans met the clinical requirements. The region of interest in uRT-TPS was smaller compared with Monaco-TPS (P<0.05). Conclusion: A comparable IMRT plan was obtained for common tumors in uRT-TPS and Monaco-TPS. It is feasible to calculate the dose of Infinity linac using uRT-TPS.

Key words: Intensity-modulated radiation therapy, uRT-treatment planning system, Monaco-treatment planning system

中图分类号:

R730.55

杨彦举, 方应涛, 高大地, 王佳舟, 赵俊, 胡伟刚. uRT-TPS和Monaco-TPS对同一直线加速器在多癌种放射剂量计算方面差异的比较[J]. 中国癌症杂志, 2024, 34(1): 82-89.

YANG Yanju, FANG Yingtao, GAO Dadi, WANG Jiazhou, ZHAO Jun, HU Weigang. Comparison of radiation dose calculation differences between uRT-TPS and Monaco-TPS for the same linear accelerator in multiple cancers[J]. China Oncology, 2024, 34(1): 82-89.

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链接本文: http://www.china-oncology.com/CN/10.19401/j.cnki.1007-3639.2024.01.005

http://www.china-oncology.com/CN/Y2024/V34/I1/82

[1]	王雁, 苏越, 胡涂, 刘绮颖, 姚伟强, 陈勇, 严望军, 章真. 33例接受术前放疗的局部高危软组织肉瘤患者近期疗效和安全性回顾性分析[J]. 中国癌症杂志, 2023, 33(7): 693-700.

uRT-TPS和Monaco-TPS对同一直线加速器在多癌种放射剂量计算方面差异的比较

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